Profiling allele-specific gene expression in brains from individuals with autism spectrum disorder reveals preferential minor allele usage
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چکیده
منابع مشابه
Allele-specific gene expression uncovered.
Genetic variation in populations can result in variation in levels of gene expression but the extent to which this occurs has been unclear. In this article, recent studies of allele-specific expression among autosomal non-imprinted genes are reviewed. These new data provide evidence that differential expression is relatively common and that allelic differences are heritable and can be highly co...
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Recent reports have shown that most of the genome is transcribed and that transcription frequently occurs concurrently on both DNA strands. In diploid genomes, the expression level of each allele conditions the degree to which sequence polymorphisms affect the phenotype. It is thus essential to quantify expression in an allele- and strand-specific manner. Using a custom-designed tiling array an...
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Natural populations hold enormous potential for evolutionary genetic studies, especially when phenotypic, genetic and environmental data are all available on the same individuals. However, untangling the genotype-phenotype relationship in natural populations remains a major challenge. Here, we describe results of an investigation of one class of phenotype, allele-specific gene expression (ASGE)...
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1Department of Pediatrics and Medical Genetics, Medical University, Plovdiv Vasil Aprilov 15-A Str., Plovdiv 4002, Bulgaria 2University Hospital “St. George” Plovdiv, 66 Peshtersko Shuse Str., Plovdiv 4000, Bulgaria 3Psychiatric ward for active treatment of men, State Phsychiatry Hospital Pazardzhik, 28 Bolnichna Str. 4400 Pazardzhik, Bulgaria 4Department of Plant Phisyology and Molecular Biolo...
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ژورنال
عنوان ژورنال: Nature Neuroscience
سال: 2019
ISSN: 1097-6256,1546-1726
DOI: 10.1038/s41593-019-0461-9